| 摘要 |
Methods and compositions for detecting blood clots in a patient are disclosed. Factor XIII or a factor XIII derivative is coupled to a substance capable of detection, such as a radioisotope or paramagnetic compound, and combined with a physiologically acceptable carrier or diluent. The resulting composition is administered to a patient to detect venous or arterial thrombosis. Also disclosed are novel factor XIII derivatives, including null mutants of factor XIII zymogen and factor XIIIa. |
