发明名称 BIS-(HYDROXYMETHYL) CYCLOBUTYL PURINES AND PYRIMIDINES
摘要 <p>Antiviral activity is exhibited by compounds having the formula <CHEM> and its pharmaceutically acceptable salts wherein R1 is <CHEM> <CHEM> wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; R3 is fluoro, chloro, bromo, iodo, hydrogen, methyl, trifluoromethyl, ethyl, n-propyl, 2-fluoroethyl, 2-chloroethyl, or <CHEM> wherein R4 is chloro, bromo, iodo, hydrogen methyl or trifluoromethyl; R5 is alkyl; R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independently hydrogen, -PO3H2 or - @-R6.</p>
申请公布号 EP0335355(A3) 申请公布日期 1991.11.13
申请号 EP19890105500 申请日期 1989.03.29
申请人 E.R. SQUIBB & SONS, INC. 发明人 SLUSARCHYK, WILLIAM ALLEN;ZAHLER, ROBERT
分类号 C07D239/47;A61K31/505;A61K31/513;A61K31/52;A61K31/522;A61K31/675;A61P31/12;A61P31/22;C07C35/04;C07C41/00;C07C43/168;C07C67/00;C07C69/02;C07D239/50;C07D239/52;C07D239/54;C07D239/545;C07D239/553;C07D239/96;C07D473/00;C07D473/02;C07D473/04;C07D473/16;C07D473/18;C07D473/30;C07D473/32;C07D473/34;C07D473/40;C07D487/04;C07F7/18;C07F9/6512;C07F9/6561;(IPC1-7):C07D473/18 主分类号 C07D239/47
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