DIARYL-SUBSTITUTED HETEROCYCLIC COMPOUNDS, DRUGS AND COSMETICS OBTAINED THEREFROM

摘要

Compounds of formula I I wherein R1 and R2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C1-C6-alkyl, or C1-C4-alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom, R3 is hydrogen, a hydroxy or C1-C6-alkoxy group, R4 is hydrogen, C1-C4-alkyl, halogen or methoxy, R5 is hydrogen or methoxy or tert-butyl, R6 is hydrogen, methyl, nitrile or a C2-C10-ketal group or the radical -CHR7OR8-CHR7-NR9R10, -COR11, -SR12, in which R7 is hydrogen or C1-C4-alkyl, R8 is hydrogen, C1-C4-alkyl or C1-C20-alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine, R9 and R10 are each hydrogen, C1-C4-alkyl or C1-C6-alkanoyl or are each benzoyl which is unsubstituted or substituted as for R8, or R9 and R10, together with the nitrogen atom to which they are bonded, form a saturated, 5-membered or 6-membered heterocyclic radical which may contain oxygen as the second heteroatom, R11 is hydrogen, C1-C4-alkyl, -OR13 or -NR14R15, where R13 is hydrogen, unsubstituted or hydroxyl-substituted C1-C8-alkyl, aryl or aralkyl which is unsubstituted or substituted by chlorine, bromine, methyl, methoxy or nitro, substitution in the case of the aralkyl group being in the aryl moiety, and where R14 and R15 are each hydrogen, unsubstituted or hydroxyl-substituted C1-C6-alkyl or an aralkyl or aryl group which is unsubstituted or substituted as for R13, or R14 and R15, together with the nitrogen atom to which they are bonded, form a heterocyclic radical as defined above for R9 and R10, and R12 is C1-C4-alkyl, and compounds of formula Ia Ia where R3, R4, R6 and L have the abovementioned meanings and R17 is hydrogen or hydroxyl, and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.