| 摘要 |
A CHEMICAL COMPLEX OF POTASSIUM ACETYLSALICYLATE ANE PREPARATION THEREOF A substantially stable and relatively nonhygroscopic complex corresponding to substantially equimolar quantities of acetylsalicylic acid, potassium acetylsalicylate and potassium bicarbonate, which exhibits properties as a nonphysical mixture, and process for preparing it, are provided. The process comprises reacting about 1 mole of acetylsalicylic acid with about one-half mole of potassium carbonate in a major amount of organic solvent and a minor amount of water to form the aforementioned complex. The complex readily dissolves in water with formation of a neutral solution of an aspirin salt, i.e., potassium acetylsalicylate. It offers potassium acetylsalicylate in a substantially stable and relatively non-hygroscopic form for use in the management of arthritis, inflammations, analgesia, and other afflictions for which acetylsalicylic acid (aspirin) is normally used. The complex thereby enables a user to avoid the side-effects caused by the acid character of acetylsalicylic acid through the use of a product which is more stable, less hygroscopic and/or easier to prepare than the soluble neutral salts of acetylsalicylic acid used previously. |
