CHIMERIC ANTIBODIES WITH RECEPTOR BINDING LIGANDS IN PLACE OF THEIR CONSTANT REGION

摘要

The present invention provides a modified chimeric monoclonal antibody comprising wo molecules of each of two differ- ent polypeptides. The shorter polypeptides function as the light chains of t he antibody and the longer polypeptides function as the heavy chains of the antibody. Moreover; the polypeptide which functions as a heavy chain has a variable region characteristic of a first mammal and a constant region characteristic of a second mammal. Each polypeptide which functions as a light chain has a variable region characteristic of a mammal and a constant region characteristic of a mammal; wherein a receptor-binding ligand replaces at least a portion of the constant region of each of the polypeptides which function as the heavy chains of the an- tibody. Additionally, the present invention provides an immunologically reactive complex and a chimeric polypeptide. Finally, methods of using and producing the modified chimeric monoclonal antibodies; immuraologically reactive complexes, and chimer- ic polypeptides are provided herein.