| 摘要 |
A decapeptide of the amino acid sequence: H-X<1>-Leu-Thr-Ile-Asp-Lys-Lys-Gly-Thr-Gly-Ala-X<2>-Y where X<1> and X<2> each represent an optional coupling-facilitating amino acid residue and Y represents -NH2 or -OH, is disclosed. Also disclosed are monoclonal antibodies specifically binding to only one epitode of Lys<342>- alpha 1-antitrypsin, i.e. Z-protein, comprising Lys<342>; a hybridoma cell line producing said monoclonal antibodies; and a method for preparing the hybridoma cell line. Further disclosed are a method for in vitro diagnosis of alpha 1-antitrypsin deficiency, i.e. the presence in the blood of Lys<342>- alpha 1-antitrypsin, in man, and an immunoassay kit for said diagnosis. |
