| 摘要 |
PURPOSE:A stable anticoagulant, containing a heparin antithrombine III low affinitive heparin as an active constituent, having a weak hemorrhagic tendency as a side effect without causing the thrombotic tendency due to the reduction in the antithrombine III. CONSTITUTION:A stable anticoagulant of blood containing an antithrombine III (abbreviated to ATIII) low affinitive heparin which will not be adsorbed by an antithrombine III linked to the lattice, e.g. ''Sepharose 4B '', in a physiologically salt concentration (sodium chloride concentration of 0.05-0.20M) at a pH of 7-8. ATIII is capable of inhibiting almost all the blood coagulating factors, and the inhibitory action is catalyzed by a heparin. On the other hand, the direct bonding to the ATIII reduces the concentration of free ATIII in blood, and the hemorhagic tendency is increased as a reactive phenomenon. The ATIII low affinitive heparin not only has a low affinity for the ATIII but also exhibits no inhibitory activity against the exogenous coagulation and exhibits the inhibitory activity specifically against the endogenous coagulation. |
