Dehydrated liposomes are prepared from a liposome preparation composed of liposomes which have multiple lipid layers and removing water from the preparation without prior freezing of the preparation, the water being removed to an end point which results in sufficient water being left in the preparation so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration. The dehydrated liposomes may contain a protective sugar. The liposomes are useful in that they can be loaded for example with drugs to provide pharmaceutical preparations.
申请公布号
CA1283604(C)
申请公布日期
1991.04.30
申请号
CA19900615683
申请日期
1990.03.23
申请人
JANOFF, ANDREW S.
发明人
JANOFF, ANDREW S.;CULLIS, PIETER R.;BALLY, MARCEL B.;FOUNTAIN, MICHAEL W.;GINSBERG, RICHARD S.;HOPE, MICHAEL J.;MADDEN, THOMAS D.;SCHIEREN, HUGE P.;JABLONSKI, REGINA L.
