摘要 |
<p>Intermediates of the structural formula II, III, IV, VIII, XI, or XII, wherein said compound has an asymmetric center(s) as indicated by the single asterisk (*) and the double asterisk (**) and wherein the compound is substantially free from compound(s) having the same chemical structure but having other absolute stereochemical configurations at the asterisked carbon centers: <CHEM> or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, substituted phenyl, 3-thienyl, substituted 3- thienyl, 3-furanyl or substituted 3-furanyl; R represents alkyl or cycloalkyl; R<1> represents H or alkyl; X represents chloro, bromo or iodo; X<1> represents OH, chloro, bromo, iodo or P<1> where P<1> represents alkoxy-substituted phenyloxy, benzyloxy, substituted benzyloxy, acyloxy, alkylthio, phenylthio, substituted phenylthio or -NHP<2> where P<2> is an amino protecting group; and P represents H or a hydroxy protecting group; and processes for making chemically pure, enantiomeric antifungal compounds.</p> |