| 发明名称 |
Purified ciliary neurotrophic factor. |
| 摘要 |
<p>A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.</p> |
| 申请公布号 |
EP0421059(A1) |
申请公布日期 |
1991.04.10 |
| 申请号 |
EP19900112353 |
申请日期 |
1990.06.28 |
| 申请人 |
SYNERGEN, INC. |
发明人 |
COLLINS FRANKLIN D.;LIN, LEU-FEN;MISMER, DRZISLAV;KO, CHRISTINE |
| 分类号 |
A61K38/00;C07K14/475;C07K16/22;C12N1/21;C12N15/12;C12N15/16;C12N15/18;C12P21/02 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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