发明名称 |
SOLUBLE MOLECULE WHICH RELATES TO BUT IS DISTINGUISH- ED FROM ICAM-1 |
摘要 |
The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1 are substantially the same. ICAM-1 is involved in the process through which lymphocytes attach to cellular substrates during inflammation and serves as the major human rhinovirus receptor (HRR). sICAM-1 therefore has both the property of reducing immune inflammation and inhibiting infection of rhinovirus and Coxsackie A virus. |
申请公布号 |
JPH0381296(A) |
申请公布日期 |
1991.04.05 |
申请号 |
JP19900014742 |
申请日期 |
1990.01.24 |
申请人 |
MOL SERAPIYUUTEIKUSU INC |
发明人 |
JIEFURII KURIIBU;ARAN MATSUKURERANDO |
分类号 |
C12P21/02;A61K38/00;A61P29/00;A61P35/00;C07K14/00;C07K14/47;C07K14/705;C07K16/00;C07K16/28;C12N5/10;C12N15/09;C12N15/12;C12P21/08;C12R1/91 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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