| 摘要 |
PURPOSE:To obtain the subject compound useful as optically active beta-blockers as a remedy for arrhythmia, hypotension and cataract by subjecting a benzyloxymethyloxazolidin-one derivative to hydrogenolysis in the presence of a palladium catalyst. CONSTITUTION:A 5-benzyloxymethyloxazolidin-2-one derivative expressed by formula I (Ph is phenyl; R<1> is H, 1-12C alkyl, aryl or aralkyl; * indicates asymmetric carbon atom) is subjected to hydrogenolysis in the presence of a palladium catalyst to afford the objective compound expressed by formula II. Furthermore, the compound expressed by formula I as the starting raw material is a new substance and can be obtained by starting from benzyl glycidyl ether provide a new 1-amino-3-benzyloxypropan-2-ol derivative and further passing the resultant derivative through a new 1-(N-alkoxycarbonyl)amino-3- benzyloxypropan-2-ol derivative. |
