RECOMBINANT RETROVIRUSES DELIVERING VECTOR CONSTRUCTS TO TARGET CELLS

摘要

Recombinant retroviruses carrying a vector con- struct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune dis- eases are disclosed. More specifically, the recombi- nant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a func- tion of a pathogenic agent, such as a virus; and (c) in- hibiting the interaction of an agent with a host cell re- ceptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a rec- ombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.