发明名称 |
CAT-MOUSE HETEROHYBRIDOMA AND GENE FRAGMENT CODING FOR CONSTANT REGION OF FELINE IMMUNOGLOBULIN |
摘要 |
The present invention is directed to: a gene fragment which includes a DNA sequence coding for an amino acid sequence of a constant region of a feline immunoglobulin .lambda. chain; a gene fragment which includes a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglubulin K chain; a gene fragment which includes a DNA sequence coding for the constant region of feline immunoglubulin .gamma. chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which includes a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein the recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene. These products and processes can be used for the diagnosis, treatment and prevention of feline diseases.
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申请公布号 |
CA2022959(A1) |
申请公布日期 |
1991.02.11 |
申请号 |
CA19902022959 |
申请日期 |
1990.08.09 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
MAEDA, HIROAKI;EDA, YASUYUKI;KIMACHI, KAZUHIKO;ONO, YOICHI;TOKIYOSHI, SACHIO |
分类号 |
C07K16/00;C07K16/08;C07K16/46;C12N5/20;C12N5/26;C12N15/13;C12P21/08;(IPC1-7):C12N15/62;C12N5/12 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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