| 摘要 |
PURPOSE:To produce compounds of optically active 3-phenylglycidic acid esters by reacting a racemic type 3-phenylglycidic acid ester with a specific enzyme, etc., and then hydrolyzing one of the optically active isomers. CONSTITUTION:A racemic 3-phenylglycidic acid ester which may have a substituent group on the phenyl group is reacted with a culture solution of an enzyme or microorganism having the ability to asymmetrically hydrolyze ester bonds, microbial cells or treated substances thereof to hydrolyze one of the optically active isomers. Antipodes are then separated and collected from the reaction solution to afford compounds of the optically active 3-phenylglycidic acid esters. The steric configuration of the separated and collected antipodes is preferably (2R, 3S). Furthermore, the enzyme is preferably esterase or lipase and the microorganism is preferably microorganisms belonging to the genuses Absidia, Aspergillus, etc. |
