PRE-S GENE CODED PEPTIDE HEPATITIS B.IMMUNOGENS VACCINE DIAGNOSTICS AND SYNTHETIC LIPID VESICLE CARRIER

摘要

A hepatitis B vaccine contains a peptide with an amino acid chain of at least six consecutive amino acids within the pre-s gene coded region of the envelope of hepatitis B virus. The vaccine is free of an amino acid sequence corresp. to the naturally occurring envelope proteins of hepatitis B virus and a diluent. The peptide is free or linked to a carrier. The carrier is a conventional carrier or a novel carrier including a lapid vesicle stabilisd by crosslinking and having covalently bonded active sites on the outer surface. This novel carrier is useful not only to link the novel peptide, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals.