| 摘要 |
<p>4-15722/CGC 1176 Pyrrolo¢1,2-a!¢4,1!benzoxazepine derivatives Disclosed are the compounds of the formula (I) wherein n represents the integer 1, 2, 3 or 4; R1 represents hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy or lower alkoxy; R2 represents hydrogen or lower alkyl; R3 represents hydrogen, lower alkyl or halogen; R4 represents amino, lower alkylamino, di-lower alkylamino, morpholino, N-lower alkyl or N-aryl-piperazino, pyrrolidino, piperidino or substituted piperidino selected from in which R5 represents hydrogen, halogen or lower alkyl; and pharmaceutically acceptable salts thereof; which are useful in mammals as calmodulin antagonists for the treatment of gastrointestinal disorders.</p> |
