发明名称 |
METHOD OF CEPHALOSPORIN'S NEW DERIVATIVES PRODUCTION |
摘要 |
<p>There are presented antibacterial cephalosporins having broad antimicrobial activity as well as intermediates for their formation, such compounds having the formula <IMAGE> I wherein R is hydrogen or a carboxylic acid-protecting group; R1 is a substituted piperazinium group of the formula <IMAGE> in which Q represents a substituted quinolinyl or naphthyridinyl group and the piperazine nucleus may be optionally substituted with one or more lower alkyl groups; R2 is selected from the group consisting of hydrogen, lower alkoxy, lower alkylthio and amido; R3is hydrogen or an acyl group; and m is 0, 1 or 2, preferably 0; as well as the corresponding readily hydrolyzable esters, pharmaceutically acceptable salts and hydrates of these compounds.</p> |
申请公布号 |
CS8901893(A2) |
申请公布日期 |
1990.08.14 |
申请号 |
CS19890001893 |
申请日期 |
1989.03.28 |
申请人 |
F. HOFFMANN-LA ROCHE AG,CH |
发明人 |
ALBRECHT HARRY A.,US;KEITH DENNIS D.,US;KONZELMANN FREDERICK M.,US;ROSSMAN PAMELA L.,US;WEI CHUNG-CHEN,US;WEIGELE MANFRED,US;YANG ROXANA,US |
分类号 |
C07D501/06;A61K31/546;C07D501/18;C07D501/34;C07D501/46;C07D519/00;(IPC1-7):C07D501/34 |
主分类号 |
C07D501/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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