发明名称 HETEROARYL 1-AMINO-3-ACYQUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF GASTRIC SECRETION
摘要 Compounds of structure (I) <CHEM> in which R<1> is hydrogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxylC1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-6alkyl, phenyl or phenylC1-6alkyl, the phenyl groups being optionally substituted; R<2> is hydrogen, C1-6alkyl, C1-6alkoxy, CO2H or CO2C1-6alkyl; m is 1, 2 or 3; p is 0 to 4; R<3> is hydrogen, C1-6alkyl, phenyl, C1-6alkoxy, C1-6alkylthio, C1-6alkanoyl, amino, C1-6alkylamino, di-C1-6alkylamino, halogen, trifluoromethyl or cyano; n is 1 or 2; and X is S, O, NH or NC1-4alkyl; processes for their preparation, intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy as anti-ulcer agents.
申请公布号 ZA8901442(B) 申请公布日期 1990.06.27
申请号 ZA19890001442 申请日期 1989.02.24
申请人 SMITHKLINE BECKMAN INTERCREDIT B.V. 发明人 ROBERT JOHN IFE;THOMAS HENRY BROWN;COLIN ANDREW LEACH
分类号 A61K31/47;A61P1/00;C07D401/12;C07D405/12;C07D409/12 主分类号 A61K31/47
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