发明名称 |
TRANSGENIC NON-HUMAN ANIMALS DEPLETED IN A MATURE LYMPHOCYTIC CELL-TYPE |
摘要 |
Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte. |
申请公布号 |
AU4755790(A) |
申请公布日期 |
1990.06.26 |
申请号 |
AU19900047557 |
申请日期 |
1989.11.22 |
申请人 |
GENPHARM INTERNATIONAL |
发明人 |
PAULUS JACOBUS ANGELINUS KRIMPENFORT;ANTONIUS JOSEF MARIA BERNS |
分类号 |
A01K67/027;C07K14/725;C07K16/00;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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