| 摘要 |
<p>PURPOSE:To provide the subject compound useful as a raw material for antiviral agents, carcinostatic agents, etc., by reacting a halogenodeoxyribose derivative with an adenine derivative in the presence of an amine in a solvent such as trichlorobenzene and subsequently removing protecting groups from the reaction product. CONSTITUTION:A 1-alpha-halogen-2-deoxyribose derivative of formula I (R<1> and R<2> are protected OH; X is halogen) is reacted with an adenine derivative of formula II (R<3> is trifluorosilyl) in the presence of an amine of formula III (R<4> is alkyl or triorganosilyl; n is 0-3) in 1,2,4-trichlorobenzene as a solvent to prepare a 3',5'-disubstituted-2'-deoxy-beta-adenosine, which is subjected to a protecting group-removing reaction to provide the objective compound of formula V.</p> |
