COMBINATION OF MEDICAL COMPOUND WITH DIPHOSPHONIC ACID DERIVATIVE

摘要

NEW MATERIAL:A compound expressed by formula I (A-CO-represents residue of a medical compound; R represents -NH- or -O-; m is 0 or 1; n is 1-10) and salts thereof. EXAMPLE:Disodium salt of [alpha-(3',6'-dihydroxy-3-oxo-spiro[phthalan-1,9'- xanthene]-6-carbonyloxy)acetamidomethylene]bis(phosphonic acid). USE:An anti-inflammatory agent, remedy for osteopathy and carcinostatic agent. PREPARATION:A compound expressed by the formula A-COOH is reacted with a compound expressed by formula II (Y represents halogen) in an inert solvent such as water or methanol preferably in the presence of a base (example; sodium hydroxide or trimethylamine) at ambient temperature of while being heated to form a compound expressed by formula III, followed by elimination of a hydroxy-protecting group.