PROCESS FOR THE PREPARATION OF HYDROXY-1,2,3,4-TETRAHYDROAMINE-ACRIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

There are disclosed compounds having the formula I where n is 1 or 2; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro or trifluoromethyl; R is hydrogen, benzyl or alkanoyl of 2- 12 carbons, with the proviso that the group -OR may not be on the 1-position of the three ring system; and R1 and R2 are each independently hydrogen, loweralkyl or arylloweralkyl, but both may not be arylloweralkyl simultaneously, or alternatively R1 and R2 taken together may constitute the group @@NR3R4 where R3 and R4 are each independently loweralkyl; and a process for their preparation. The compounds can be used for the treatment of various memory dysfunctions characterized by decreased cholinergic function, such as Alzheimer's disease.