| 摘要 |
<p>D.P.C.(PhRe) 6739/A 2-AZACYCLOALKYLTHIOPENEM DERIVATIVES Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula ---I or a pharmaceutically acceptable salt thereof, wherein: R is 72222-30 A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen or sulfur; B is carbonyl or methylene; R1 is hydrogen or forms an ester group which is hydrolyzed in vivo; R2 is hydrogen, formyl or alkyl has 1-4 carbon atoms; alk is alkylene having 1-4 carbon atoms; and n is zero or one; with the proviso that R2 is formyl when s is methylene and A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent and said carbon atom is not adjacent to the nitrogen atom of R or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen or sulfur.</p> |
