FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT VERKANDE (S,S,S)-ISOMERER AV SUBSTITUERADE ACYLDERIVAT AV 1,2,3,4-TETRAHYDROISOKINOLIN-3-KARBOXYLSYROR.

摘要

There are disclosed substituted acyl derivatives of 1,2,3,4-tetrahydro-5,7-dimethoxy-3-isoquinoline-carboxylic acid having the following general formula: wherein R<2> is a hydrogen atom or a methyl or ethyl radical, and pharmaceutically acceptable salts of the compound of formula I. The substituted acyl derivatives and the pharmaceutically acceptable salts thereof may be produced by coupling a suitably substituted 1,2,3,4-tetrahydroisoquinoline with a suitably substituted amino acid and, when desired, hydrolysing or removing the protecting groups of the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as anti-hypertensive agents.