| 摘要 |
Novel polycyclic alkaloids of the formula <IMAGE> in which R denotes hydrogen, acyl, sulphonyl, sulpho or phospho, and A denotes C=O or optionally acylated C-OH, where the dashed line symbolises a C = C double bond in the position of the central bond if A is C=O, or in the position of the two outer bonds if A is optionally acylated C-OH, a process for the preparation of these compounds by cyanidation and, if appropriate, acylation or sulphonylation in any desired sequence of the fermentation product of a microorganism of the species Myxococcus xanthus, pharmaceutical preparations which contain the novel compounds, and the use of the novel compounds as antibiotics and as antitumour agents and for the production of pharmaceutical preparations, also the novel intermediates of the formula I in which CN is replaced by OH and R is acyl, sulpho or phospho substituted by carboxyl or esterified carboxyl, which likewise are pharmaceutically utilisable. |
