Bispecific hybrid monoclonal antibody.

摘要

Disclosed are a bispecific hybrid monoclonal antibody and a polydoma, preferably a trioma, for producing it. One molecule of the bispecific hybrid monoclonal antibody is capable of linking to both human lymphotoxin and an enzyme such as horseradish peroxidase, a fluorescent substance or a radionuclide. The bispecific hybrid monoclonal antibody is produced from the polydoma, particularly the trioma obtained by fusing an anti-human lymphotoxin-producing hybridoma with spleen cells of mouse immunized with horseradish peroxidase. Using this bispecific hybrid monoclonal antibody, an immunodiagnostic method for detecting the human lymphotoxin specifically, rapidly and easily, is provided.