Process for the continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl)propionic acid.

摘要

Continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid consisting in the reaction of a racemic (R,S) ester of 2-(6-methoxy-2-naphthyl) propionic acid having melting point below 50 DEG C of formula: wherein R1 = a C2-C10 alkyl, C4-C6 cycloalkyl, phenyl, tetrahydropyranyl , tetrahydrofuranyl radicals and -(CH2CH2O)n-R2 group, wherein n = 2-15 and R2 = a C1-C4 alkyl group, with the Lipase obtained from Candida Cylindracea, at temperatures ranging from 20 DEG -60 DEG C and at a pH ranging from 5 to 8, by feeding said ester in a continuous way into a bioreactor containing said Lipase immobilized on a porous carrier selected from adsorbent resins of the polyacrylester type having a porosity ranging from 50 to 1000 ANGSTROM and a granulometry ranging from 1 to 0.01 mm.