| 摘要 |
<p>PURPOSE:To readily obtain a valiolamine having inhibitory action on alpha- glucosidase, by using a novel aminocyclitol as a starting raw material, dehalogenating to give a compound, hydrolyzing the compound and optionally eliminating the protecting group. CONSTITUTION:A compound shown by formula I [R is alkyl, aryl or aralkyl which may be replaced with 1-3 of halogen, 1-4C alkyl and alkoxy; OR<1> is (protected) OH] is reacted with a halogenating agent to give an aminocyclitol shown by formula II (X is halogen) including a novel compound (novel compound when OR<1> is OH; X is H or halogen), which is then dehalogenated to give a compound shown by formula III. This compound as a raw material is hydrolyzed and optionally the protecting group is removed to give the aimed compound {=L(1S)-[1(OH),2,4,5/1,3]-5-amino-1-hydroxymethyl-1,2,3,4- cyclohexanetetrol} shown by formula IV.</p> |
