TRIPEPTIDE RENNIN INHIBITOR HAVING N-TERMINAL UREIDO OR SULFANIDE GROUP

摘要

Tripeptide enzyme inhibitors of the formula: which have N-terminal ureas or sulfamides incorporating polar groups, and analogs thereof, which inhibit renin and are useful for treating various forms of renin-associated hypertension and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel tripeptides.