CARBOXY, CARBOALKOXY AND CARBAMILE SUBSTITUTED ISONITRILE RADIONUCLIDE COMPLEXES

摘要

Coordination complexes comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: CN-X-R where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR1 and CONR2R3 where R1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R2, and R3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R2 and R3 can be the same or different are useful in visualizing cardiac tissue, studying lung function, studying renal excretion and have very fast liver or lung clearance; kits that can be used to form these complexes are also provided.