| 摘要 |
A method for the production of substantially 100% pure N alpha -urethane protected amino acids is disclosed. This method eliminates the formation of di-peptide and tri-peptide contaminants. Reaction of blocking reagents at the carboxylate site on a protected peptide is prevented by the application of labile amino acid esters. Subsequent removal of the ester yields, in ultra-high purity, the N alpha -protected amino acid. The substantially 100% pure N alpha -urethane protected amino acid are also disclosed.
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