| 摘要 |
<p>It has surprisingly been found that benzamides of the formula I wherein R1 and R2 each independently signify hydrogen, halogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, sulphamoyl, mono(lower alkyl)sulphamoyl or di(lower alkyl)sulphamoyl or R1 and R2 on adjacent carbon atoms together signify a methylenedioxy group, with the proviso that R2 is different from hydrogen when R1 signifies bromine in the 3-position, and their pharmaceutically usable acid addition salts have interesting monoamine oxidase inhibiting properties with low toxicity and can accordingly be used for the treatment of depressive states and Parkinsonism. Those compounds of formula I in which R1 signifies halogen, cyano or trifluoromethyl in the para-position and R2 signifies hydrogen or R1 and R2 together signify 2,4-dichloro, 3,4-dichloro or 3,4-methylenedioxy are novel; these novel compounds can be manufactured according to methods known per se.</p> |
