| 摘要 |
Aminoalkoxybenzopyranones of the formula
<CHEM>
or a pharmaceutically acceptable acid addition salt thereof; wherein
n is an integer from 2-5;
R is hydrogen, lower alkyl, trofluoromethyl, or lower alkoxy;
R1 is a radical of the formula
<CHEM>
in which --- represents a single or double bond, Ar is phenyl or phenyl substituted by lower alkyl, lower alkoxy, lower thioalkoxy, halogen, or triflouromethyl, and in which Het is chosen from the following heterocyclic radicals (a) 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, or halogen, (b) 2-, 4-, or 5-pyrimidinyl, or 2-, 4-, or 5-pyrimidinyl substituted by lower alkyl, lower alkoxy, or halogen, (c) 2-pyrazinyl or 2-pyrazinyl substituted by lower alkyl, lower alkoxy, or halogen, (d) 2- or 3-thienyl, or 2- or 3-thienyl substituted by lower alkyl or halogen, (e) 2- or 3-furanyl, or 2- or 3-furanyl substituted by lower alkyl or halogen, or (f) 2- or 5-thiazolyl or 2- or 5-thiazolyl substituted by lower alkyl or halogen; with the exclusion of the compound in which n is 3, R is methyl, and R1 is a radical of the formula
<CHEM>
in which Ar is phenyl.
<??>Also described are processes for producing the compounds, and pharmaceutical compositions comprising the compounds. |
