| 摘要 |
PURPOSE:To obtain a stable aqueous composition of thrombin useful as a local hemostatic, by blending an aqueous solution containing thrombin with a saccharide and an amino acid as a stabilizer. CONSTITUTION:Thrombin having about 100-1,000 unit/mg specific activity is used as thrombin and an aqueous solution containing thrombin is prepared by a well-known method. In the operation, a saccharide such as glucose, maltose or sorbitol and an amino acid such as glycine, aspartic acid or arginine are used as a stabilizer and added to the aqueous solution. The aqueous solution has pH 5-8 (especially 6-7). To maintain the pH, a buffer solution of phosphoric acid or citric acid is used.
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