发明名称 |
A method for detecting the predisposition to retinoblastoma and a method for detecting a retinoblastoma gene in tumors using a retinoblastoma gene probe. |
摘要 |
<p>A Method of and a kit for detecting the predisposition to retinoblastoma. A method for detecting a defect in the retinoblastoma gene in retinoblastoma, osteosarcoma, fibrosarcoma, melanoma, soft tissue sarcoma, small-cell carcinoma and mammary tumors. The method includes hybridizing a retinoblastoma gene probe to DNA extracted from target tissue and then determining binding of the probe to the DNA. The target tissue can be tumor or non-tumor tissue and from a fetus to an adult. Further there are DNA probes of 4.6, 3.8, and 0.9 kb.</p> |
申请公布号 |
EP0293266(A2) |
申请公布日期 |
1988.11.30 |
申请号 |
EP19880304900 |
申请日期 |
1988.05.27 |
申请人 |
CLAYTON FOUNDATION FOR RESEARCH |
发明人 |
FUNG, YUEN KAI T.;T'ANG, ANNE;MURPHREE, LINN A.;BENEDICT, WILLIAM F. |
分类号 |
C12N15/09;A61K31/70;A61P35/00;C07H21/00;C07H21/04;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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