NOVEL 4'-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

摘要

The present invention relates to novel 4 min -demethyl-4-epipodophyllotoxin derivatives of the general formula I …… wheren R represents a lower alkyl group, X1 represents a hydroxyl group or an amino group, with the proviso that when one of X1 and X2 represents an amino group, the other represents a hydroxy group, and when one of them represents a hydroxy group, the other represents an amino group, or the salts thereof, and to a process for their preparation. The compounds exhibit excellent antitumor activity.