发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV 17-SUBSTITUERADE ANDROSTA-1,4-DIEN-3-ONDERIVAT. |
摘要 |
<p>The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula <CHEM> wherein each of R and R3, independently, is hydrogen or C1-C6 alkyl; R1 is hydrogen, halogen or C1-C6 alkyl; R2 is hydrogen or C1-C6 alkyl; R4 is hydrogen or fluorine; R5 is a) hydrogen or C1-C6 alkyl; b) phenyl unsubstituted or substituted by one or two substituents independently chosen from C1-C6 alkyl, halogen and amino; c) an acyl group; or d) a hydroxy protecting group; and the pharmaceutically acceptable salts thereof, which are useful in therapy, in particular as anti-cancer agents.</p> |
申请公布号 |
FI884088(A0) |
申请公布日期 |
1988.09.06 |
申请号 |
FI19880004088 |
申请日期 |
1988.09.06 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
VILLA, VITTORIA;DI SALLE, ENRICO;LOMBARDI, PAOLO |
分类号 |
A61K31/565;A61P35/00;C07J1/00;C07J17/00;C07J31/00;C07J41/00;C07J71/00;(IPC1-7):C07J/ |
主分类号 |
A61K31/565 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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