| 摘要 |
PURPOSE:To obtain the titled compound useful as an intermediate for producing cephalosporin compounds by the use of readily obtainable raw materials industrially and advantageously, by decarbonating 5-(4-pyridyl)oxazole-4-carboxylic acid. CONSTITUTION:A compound shown by formula CN-CH2CO2R (R is alkyl) is reacted with an isonicotinic acid activator (preferably isonicotinic acid chloride) to give a compound shown by formula I. This compound is hydrolyzed to give 5-(4-pyridyl)oxazole-4-carboxylic acid shown by formula II. Then this compound is decarbonated in a solvent such as DMF, in the presence of both metallic powder such as copper powder, and a base such as pyridine, preferably at 150-200 deg.C for 30min-50hr to give the aimed 5-(4-pyridyl)oxazole.
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