发明名称 |
PROCESS FOR PRODUCTION OF 1,2-DIHYDROXI-3-//2-INDOLIL-1,1-DIALKYL-ETHIL/-AMIN/-PROPHANES |
摘要 |
1-(Pyridinyloxy)-3-(indolylalkylamino)- 2-propanols, novel cardiovascular agents having vasodilator activity and a range of adrenergic beta-receptor blocking action, are prepared by any one of three routes that comprise a novel general process. The general process comprises coupling a hydroxyl- or halogen- substituted pyridine with a suitable halogen- or hydroxyl-substituted propanol or incipient propanol intermediate; and the products of these couplings are also novel. In the preferred of the three coupling routes, product 1-(pyridinyloxy)-3-(indolyl- alkylamino)-2-propanols are formed directly; in the other two coupling routes further processing of the coupling products is required to form the 1-(pyridinyloxy)-3-(indolylalkylamino)- 2-propanols. Preferred compounds bear an amide or cyano substituent in the 3-position of the pyridine ring. |
申请公布号 |
HU194164(B) |
申请公布日期 |
1988.01.28 |
申请号 |
HU19860004311 |
申请日期 |
1983.09.02 |
申请人 |
BRISTOL-MYERS CO,US |
发明人 |
KREIGHBAUM,WILLIAM E.,US |
分类号 |
C07D413/14;A61K31/44;A61K31/4427;A61K31/443;A61P9/08;A61P9/12;A61P25/02;C07D209/14;C07D401/12;C07D403/00;C07D405/12 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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