Purified sorbine, new peptides having common peptide sequences with sorbine and pharmaceutical compositions containing them

摘要

The invention relates to an essentially pure peptide consisting of a certain number of well-defined peptide fragments which have not yet been completely joined to each other; > M.R.A.A.T.P.L.Q.T.V.D.R.P.K.D.T.Y.K.T.M.F.K.Q.I.H.M.V.H. K.P.D.D.D.T.M.... ... M.Y.N.T.P.Y.T.Y.N.A.G.L.Y.N.S.P.Y.S.A.Q.S.H.P.A.A.K.T.- Q.T.Y.R.P. L.S. (R or K)... ... D.A.S.S.P.V.P.P.P.H.V.P.P.P.V.P.P.L.R... K.V.P.F.R. ..S.A.K.E.H.E.T.K.. .T.Q.L.P.R.Y.T.S.K... .S.H.S.D.N.G.T.D.A.F.K... K.H.D.R.D.P.P.D.R.K.V.D.T.R.K.F.R.S.E.P.R.S.I.F.E.Y.E.P.G.K.- S.S.I.L.Q.H.E.R.P.V.T.K.P.Q.A.-NH<2>. The invention relates to the fragment consisting of the last 40 amino acids and which contains the activity of the entire molecule with respect to intestinal absorption: P.P.D.R.K.V.D.T.R.K.F.R.S.E.P.R. S.I.F.E.Y.E.P.G.K.S.S.I.L.Q.H.E.R.P.V.T.K.P.Q.A-NH<2>. The invention also relates to pharmaceutical preparations containing an effective dose of one of these peptides for the treatment of diarrhoea or malabsorptions.