| 摘要 |
<p>In the preparation of a pharmaceutical compositions to the treatment of hypoxia there is used, as active ingredient, a compound of the formula:
<CHEM>
in which R<1> is a hydrogen atom or a lower alkyl, lower alkenyl, lower alkynyl or phenyl-lower alkyl group.
<??>Z is a group of the formula
<CHEM>
(in which R<2> is a hydrogen atom or a lower alkyl group; and the bond @ is a single or double bond), a group -(CH2)3-, -O-CH2- or -S-CH2-;
R<3> is a pyridyl group, or a phenyl group optionally substituted with up to three substituents selected from halogen atoms and lower alkyl, lower alkoxy and hydroxy groups;
the group
<CHEM>
is a group
<CHEM>
and A is a lower alkylene group;
provided that when the group
<CHEM>
is a group
<CHEM>
then Z is a group of the formula
<CHEM>
and R<3> is neither a pyridyl group nor a phenyl group having a hydroxy group as the substituent; or provided that when R<3> is a pyridyl group, then Z is a group of the formula </p> |
