NEW AZULENE DERIVATIVES USEFUL AS ANTI-ULCERATIVE AND ANTI-FLAMMATORY AGENTS

摘要

New azulene derivatives of the general formula

where: R<1> is a lower alkyl group, a group of the general formula

or a benzyl group, R<5>, R<6> and R<7> each representing H or a lower alkyl group and n being 1 or 2;
R<2> and R<3> each represents H or a lower alkyl group;
R<4> is H or an alkoxy group;
and X is Na or Al(OH)2 are stable to light and heat and are useful as anti-ulcerative and anti-inflammatory agents.
The azulene derivatives may be prepared by reacting a compound of the formula

wherein R<1>, R<2>, R<3> and R<4> are as defined above with a sulfonating agent and converting the resulting sulfonic acid to its sodium or aluminium salt.