发明名称 |
Iron derivatives of globin and of acetylglobin endowed with high bioavailability process for their preparation and pharmaceutical formulations. |
摘要 |
<p>Iron derivatives of globin and of acetylglobin endowed with high bioavailability, containing quantity of iron changing from 2 to 20% in weight, are useful pharmaceutical compositions to treat iron deficency anemia.
<??>The process for obtaining the above mentioned iron derivatives has been carried out through the following phases;
a) Preparation of globin starting from red blood cells of animals;
b) Preparation of acetylglobin through the acetylation of globin;
c) Preparation of iron glucidic dervatives;
d) Preparation of iron acetylglobin and of iron globin through the reaction respectively of acetylglobin and globin with ironglucidic derivatives or with inorganic iron salts.
<??>The products thus obtained have an high solubility at neutral and alkaline pH and, orally administered, increase the basal iron levels in the serum without damaging the gastrointestinal system. </p> |
申请公布号 |
EP0223153(A2) |
申请公布日期 |
1987.05.27 |
申请号 |
EP19860115334 |
申请日期 |
1986.11.05 |
申请人 |
MEDIOLANUM FARMACEUTICI S.R.L. |
发明人 |
DE AMBROSI, LUIGI;PAGELLA, PIERGIUSEPPE |
分类号 |
C07K1/113;A61K38/00;A61K38/16;A61K38/42;A61P7/06;C07K14/00;C07K14/805 |
主分类号 |
C07K1/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|