| 发明名称 |
Irreversible dopamine-B-hydroxylase inhibitors. |
| 摘要 |
<p>Compounds of the formula:
<CHEM>
in which X is hydrogen or hydroxy; a process for their preparation; intermediates useful in their preparation; pharmaceutical compositions containing them; and their use in therapy as inhibitors of dopamine- beta -hydroxylase activity in mammals. </p> |
| 申请公布号 |
EP0219961(A1) |
申请公布日期 |
1987.04.29 |
| 申请号 |
EP19860306923 |
申请日期 |
1986.09.08 |
| 申请人 |
SMITHKLINE BECKMAN CORPORATION |
发明人 |
CHAMBERS, PAMELA ANNE;FRAZEE, JAMES SIMPSON;KAISER, CARL;KRUSE, LAWRENCE IVAN |
| 分类号 |
A61K31/275;A61K31/375;A61P9/00;A61P9/12;A61P43/00;C07C45/00;C07C45/71;C07C47/575;C07C67/00;C07C69/734;C07C69/736;C07C253/00;C07C255/41;C07C255/42;C07C255/43;C07C255/53;C07C255/59;(IPC1-7):C07C121/80;C07C121/75;C07C125/067;C07C120/00 |
主分类号 |
A61K31/275 |
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