Tripeptidic compounds having hypotensive activity.

摘要

Tripeptides having hypotensive activity, to be defined by the following general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="7" wi="31" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein:
<UnorderedLists id="ula01" listStyle="none"><ListItem>A represents a residue of L-pyroglutamic acid, L-proline or L-proline bearing a substituent on its amino group
<Chemistry id="chema02" num="0002"><Image id="ia02" he="22" wi="66" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><!-- EPO <DP n="2"> --><ListItem>wherein R, is an acyl with a number of carbon atoms in straight chain not higher than 9, a benzyloxycarbonyl group or an alkyloxycarbonyl group;</ListItem><ListItem>B is an a-aminoacidic residue deriving from one of the natural aminoacids;</ListItem><ListItem>C is a residue of L-tryptophan (Trp), of L-phenylalanine (Phe) or of L-tyrosine (Tyr);</ListItem><ListItem>Z is a hydrogen atom or an alkyl group with a number of carbon atoms in straight chain not higher than 9.</ListItem></UnorderedLists>