| 摘要 |
<p>The invention concerns novel [5,6]-cis-1,3-oxathiane derivatives of formula I in which R<Sup>1</Sup> and R<Sup>2 </Sup>are variously defined as hydrogen, alkyl, trifluoromethyl or phenyl (as set our in the specification), n is 1 or 2, m is 2, 3 or 4, Y is vinylene and Z is carboxy, 1 (H)-tetrazol-5-yl or a group of the formula CO. NH. S0<Sub>2</Sub>R<Sup>3</Sup> in which R<Sup>3</Sup> is alkyl, phenyl or benzyl, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.</p> |
