发明名称 |
Acid-cleavable compound |
摘要 |
Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structure. Finally, a method of characterizing complex multi-chain protein structures is disclosed.
|
申请公布号 |
US4618492(A) |
申请公布日期 |
1986.10.21 |
申请号 |
US19850733479 |
申请日期 |
1985.05.13 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
BLATTLER, WALTER A.;LAMBERT, JOHN M.;SENTER, PETER D. |
分类号 |
C07K14/00;A61K31/194;A61K31/195;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K38/00;A61K38/36;A61K39/00;A61K39/395;A61K45/00;A61K47/48;A61P35/00;C07C229/42;C07C323/36;C07D207/44;C07D207/452;C07D405/00;C07D405/12;C07H15/252;C07K1/107;C07K1/113;C07K9/00;C07K14/415;C07K16/00;(IPC1-7):C07D519/00;C07D521/00 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|