| 摘要 |
PURPOSE:A rapid-acting and easily absorbable granule consisting of a spherial core agent and fine powder of nifedipine sticking to the surface thereof and a sustained release compound granule of nifedipine using same. CONSTITUTION:A sustained release compound granule of nifedipine consisting of rapid-acting spherical granules consisting of a spherical core agent and fine powder of nifedipine sticking to the surface thereof and slow-acting spherical granules obtained by coating the above-mentioned rapid-acting spherical granules with an enteric substance and/or slightly soluble substance, and containing 10-90wt% preferably 10-50wt%, based on the total granules, rapid-acting spherical granules. The final grain size of the above-mentioned granules is preferably 12-150 mesh, particularly 12-80 mesh. The above-mentioned rapid- acting spherical granules are very easily absorbable and rapid acting and therefore may be formulated into a capsule, etc. Stick packages or packs divided into sachets as one unit can be easily and smoothly put into and administered to the interior of the mouth.
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