发明名称 |
NOVEL PROCESS AND INTERMEDIATES USEFUL IN THE PREPARATION OF SYMPATHOMIMETIC AMINES |
摘要 |
The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom. |
申请公布号 |
DE3071568(D1) |
申请公布日期 |
1986.05.28 |
申请号 |
DE19803071568 |
申请日期 |
1980.09.24 |
申请人 |
INTERX RESEARCH CORPORATION |
发明人 |
ZUPAN, JACOB A. |
分类号 |
C07C271/16;C07C67/00;C07C239/00;C07C271/06;C07C309/63;(IPC1-7):C07D307/62;C07C143/68;C07D401/12;C07D213/79;C07D213/80;C07D213/46;C07C69/75;C07C69/035;C07C69/78;C07C101/62;C07C125/065 |
主分类号 |
C07C271/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|